{Reference Type}: Journal Article
{Title}: Identification of concurrent STAT3::RARA and RARA::STAT5b fusions in a variant APL case.
{Author}: Tao T;Cen J;Xu C;Chen Y;Cao Y;Gong Y;Zhu M;Chen S;Zhang Q;Yao L;
{Journal}: Mol Carcinog
{Volume}: 63
{Issue}: 4
{Year}: 2024 Apr 28
{Factor}: 5.139
{DOI}: 10.1002/mc.23672
{Abstract}: Acute promyelocytic leukemia (APL) with typically PML::RARA fusion gene caused by t (15;17) (q22; q12) was distinguished from other types of acute myeloid leukemia. In a subset of patients with APL, t (15;17) (q22;q21) and PML::RARA fusion cannot be detected. In this report, we identified the coexistence of STAT3::RARA and RARA::STAT5b fusions for the first time in a variant APL patient lacking t (15;17)(q22;q21)/PML::RARA fusion. Then, this patient was resistant to all-trans retinoic acid combined arsenic trioxide chemotherapy. Accurate detection of RARA gene partners is crucial for variant APL, and effective therapeutic regime is urgently needed.