{Reference Type}: Journal Article {Title}: Letter to the editor: Aggressive variant prostate cancer: An exemplary case study and comprehensive literature survey. {Author}: Ke HW;Zhang WY;Xu KX; {Journal}: World J Clin Cases {Volume}: 11 {Issue}: 35 {Year}: 2023 Dec 16 {Factor}: 1.534 {DOI}: 10.12998/wjcc.v11.i35.8431 {Abstract}: This article enthusiastically explores the study of highly aggressive variant prostate cancer (AVPC), acknowledging its relatively rare yet highly menacing presence within the realm of prostate cancer. The paper delves into the pathological characteristics of AVPC, diagnostic and therapeutic challenges, and the potential applications of precision medicine and molecular imaging in the future.