{Reference Type}: Case Reports
{Title}: An extranodal Richter's syndrome presenting with cardiac diffuse large B-cell lymphoma: a case report.
{Author}: Wang H;Yan WH;Sun JJ;Dong M;Zhang N;Liu T;Song NP;Zhong L;
{Journal}: BMC Cardiovasc Disord
{Volume}: 23
{Issue}: 1
{Year}: 2023 12 21
{Factor}: 2.174
{DOI}: 10.1186/s12872-023-03663-4
{Abstract}: Richter's syndrome (RS) defines the transformation of chronic lymphocytic leukemia into high-grade lymphoma, which usually involves lymph nodes and bone marrow. Extranodal involvement of the heart is an extremely rare condition. Patients with heart involvement tended to have a low response to chemotherapy and relative poor prognosis. The transformation process of RS is often insidious and nonspecific making it challenging to diagnose.<BR>A 64-year-old woman wih a history of chronic lymphocytic leukemia (CLL) presented with intermittent chest pain and was diagnosed with non-ST-elevation myocardial infarction (NSTEMI). However, the contrast enhanced echocardiography revealed a large irregular mass, measuring about 75.4 mm × 37.5 mm, located on the lateral and posterior wall of the right ventricle. Biopsy of the cardiac mass and the results revealed diffuse large B-cell lymphoma.<BR>We present a case of a 64-year-old woman with aggressive diffuse large B-cell lymphoma involving the heart. This case could provide some insights in the diagnosis of cardiac lymphoma.