{Reference Type}: Case Reports {Title}: Extracorporeal photopheresis: Is one ounce of blood enough? Case reports. {Author}: Kumukova I;Kurnikova E;Trakhtman P; {Journal}: Pediatr Blood Cancer {Volume}: 71 {Issue}: 3 {Year}: 2024 Mar 17 {Factor}: 3.838 {DOI}: 10.1002/pbc.30800 {Abstract}: Extracorporeal photopheresis (ECP) has proven effective in the treatment of several diseases, including acute and chronic graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation. In its standard version, ECP requires leukapheresis to obtain a fraction of mononuclear cells. The possibility of using leukapheresis is limited by the requirements for vascular access and the somatic status of the patient. We have developed a new ECP method that does not require leukapheresis. This paper presents a description of two clinical cases of severe refractory GVHD treated by micro-ECP.