{Reference Type}: Case Reports
{Title}: Cardiogenic shock after 5-fluorouracil administration: a case report and literature review.
{Author}: Vanoverbeke L;Wouter H;François D;Ivan E;
{Journal}: Eur Heart J Case Rep
{Volume}: 7
{Issue}: 12
{Year}: 2023 Dec
暂无{DOI}: 10.1093/ehjcr/ytad596
{Abstract}: <B>UNASSIGNED: </B>Cardiogenic shock is a rare adverse event of 5-fluorouracil (5-FU) administration. Because of its rare entity, little is known about epidemiologic and clinical features of 5-FU-induced cardiogenic shock, and recommendations about specific treatment are missing.<BR><B>UNASSIGNED: </B>We present a case of cardiogenic shock and ventricular arrhythmia due to 5-FU-induced toxic cardiomyopathy treated with vasopressor and inotropic drugs in combination with intra-aortic balloon pump. Because of persistent haemodynamic instability, veno-arterial extracorporeal membrane oxygenation (VA-ECMO) and Impella were implanted as a bridge to recovery. Systolic function recovered completely and the patient was weaned successfully.<BR><B>UNASSIGNED: </B>This case demonstrates toxic cardiomyopathy as a rare and potentially lethal cardiac adverse event of 5-FU administration. This case emphasizes the importance of mechanical support as bridging therapy to recovery of cardiac function.