{Reference Type}: Journal Article
{Title}: Postnatal persistence of hippocampal Cajal-Retzius cells has a crucial role in the establishment of the hippocampal circuit.
{Author}: Glærum IL;Dunville K;Moan K;Krause M;Montaldo NP;Kirikae H;Nigro MJ;Sætrom P;van Loon B;Quattrocolo G;
{Journal}: Development
{Volume}: 151
{Issue}: 1
{Year}: 2024 Jan 1
{Factor}: 6.862
{DOI}: 10.1242/dev.202236
{Abstract}: Cajal-Retzius (CR) cells are a transient neuron type that populate the postnatal hippocampus. To understand how the persistence of CR cells influences the maturation of hippocampal circuits, we combined a specific transgenic mouse line with viral vector injection to selectively ablate CR cells from the postnatal hippocampus. We observed layer-specific changes in the dendritic complexity and spine density of CA1 pyramidal cells. In addition, transcriptomic analysis highlighted significant changes in the expression of synapse-related genes across development. Finally, we were able to identify significant changes in the expression levels of latrophilin 2, a postsynaptic guidance molecule known for its role in the entorhinal-hippocampal connectivity. These findings were supported by changes in the synaptic proteomic content in CA1 stratum lacunosum-moleculare. Our results reveal a crucial role for CR cells in the establishment of the hippocampal network.