{Reference Type}: Journal Article
{Title}: Gene polymorphism of MTHFR rs1801133 and susceptibility to childhood leukemia in Chinese population.
{Author}: Peng Y;Wang C;Wu L;
{Journal}: J Med Biochem
{Volume}: 42
{Issue}: 4
{Year}: 2023 Oct 27
{Factor}: 2.157
{DOI}: 10.5937/jomb0-41672
{Abstract}: <B>UNASSIGNED: </B>The purpose of this study is to investigate the genotype and allele distribution of MTHFR rs1801133 in the Chinese population, and to analyze the relationship between gene polymorphism of MTHFR rs1801133 and risk of childhood leukemia.<BR><B>UNASSIGNED: </B>Blood samples and clinical data of childhood leukemia cases (n=1132) and age-matched healthy controls (n=1053) were collected. Genotypes and allele distribution of MTHFR rs1801133 were detected by PCR-RFLP. Logistic regression model was generated to analyze the relation between MTHFR rs1801133 and susceptibility to childhood leukemia and the chemotherapy response.<BR><B>UNASSIGNED: </B>Age, sex, BMI and family history of tumor were comparable between childhood leukemia cases and healthy controls. Genotypes and allele distribution of MTHFR rs1801133 were remarkably correlated to the risk of childhood leukemia. Genotype risk of MTHFR rs1801133 was parallel to the susceptibility to childhood leukemia. Specifically, compared with people carrying AA allele of MTHFR rs1801133, higher risk of childhood leukemia may occur in people carrying AG+GG allele of MTHFR rs1801133 with a younger age (<15 years) or complete remission from chemotherapy.<BR><B>UNASSIGNED: </B>MTHFR rs1801133 gene polymorphism has a significant correlation with childhood leukemia. It is an important genetic susceptibility gene of childhood leukemia. The reliability of the results requires to be further validated by the high-quality research involving a large sample size in multi-center hospitals.<BR><B>UNASSIGNED: </B>Svrha ove studije je da se ispita distribucija genotipa i alela MTHFR rs1801133 u kineskoj populaciji i da se analizira odnos između polimorfizma gena MTHFR rs1801133 i rizika od leukemije u detinjstvu.<BR><B>UNASSIGNED: </B>Prikupljeni su uzorci krvi i klinički podaci slučajeva leukemije u detinjstvu (n = 1132) i zdravih kontrola odgovarajućeg uzrasta (n = 1053). Genotipovi i distribucija alela MTHFR rs1801133 detektovani su PCR-RFLP Model logističke regresije je generisan da analizira odnos između MTHFR rs1801133 i osetljivosti na leukemiju u detinjstvu i odgovora na hemoterapiju.<BR><B>UNASSIGNED: </B>Starost, pol, BMI i porodična istorija tumora bili su uporedivi između slučajeva leukemije u detinjstvu i zdravih kontrola. Genotipovi i distribucija alela MTHFR rs1801133 bili su u značajnoj korelaciji sa rizikom od leukemije u detinjstvu. Rizik od genotipa MTHFR rs1801133 bio je paralelan sa osetljivošću na leukemiju u detinjstvu. Konkretno, u poređenju sa ljudima koji nose AA alel MTHFR rs1801133, veći rizik od leukemije u detinjstvu može se javiti kod ljudi koji nose AG+GG alel MTHFR rs1801133 mlađe starosti (<15 godina) ili potpune remisije od hemoterapije.<BR><B>UNASSIGNED: </B>Polimorfizam gena MTHFR rs1801133 ima značajnu korelaciju sa dečjom leukemijom. To je važan gen genetske osetljivosti na dečju leukemiju. Pouzdanost rezultata treba da bude dodatno potvrđena visokokvalitetnim istraživanjem koje uključuje veliki uzorak u bolnicama sa više centara.