{Reference Type}: Journal Article
{Title}: The role of angiotensin receptor blockers in treating epilepsy: a review.
{Author}: Shaikh TG;Hasan SFS;Ahmed H;Kazi AI;Mansoor R;
{Journal}: Neurol Sci
{Volume}: 45
{Issue}: 4
{Year}: 2024 Apr 11
{Factor}: 3.83
{DOI}: 10.1007/s10072-023-07249-y
{Abstract}: Epilepsy is a chronic brain disease with a global prevalence of 70 million people. According to the World Health Organization, roughly 5 million new cases are diagnosed every year. Anti-seizure drugs are the treatment of choice. However, in roughly one third of the patients, these drugs fail to produce the desired effect. As a result, finding novel treatments for epilepsy becomes inevitable. Recently, angiotensin receptor blockers have been proposed as a treatment to reduce the over-excitation of neurons in epilepsy. For this purpose, we conducted a review using Medline/PubMed and Google Scholar using the relevant search terms and extracted the relevant data in a table. Our review suggests that this novel approach has a very high potential to treat epilepsy, especially in those patients who fail to respond to conventional treatment options. However, more extensive and human-based trials should be conducted to reach a decisive conclusion. Nevertheless, the use of ARBs in patients with epilepsy should be carefully monitored keeping the adverse effects in mind.