{Reference Type}: Journal Article
{Title}: Diborodichloromethane as Versatile Reagent for Chemodivergent Synthesis of gem-Diborylalkanes.
{Author}: Fang T;Wang L;Wu M;Qi X;Liu C;
{Journal}: Angew Chem Int Ed Engl
{Volume}: 63
{Issue}: 3
{Year}: 2024 Jan 15
{Factor}: 16.823
{DOI}: 10.1002/anie.202315227
{Abstract}: The development of boron reagents is crucial for synthetic chemistry. Herein, we present a scalable and practical synthesis of diborodichloromethane (DBDCM) through the reaction of trichloromethyllithium with bis(pinacolato)diboron (B2 pin2 ). The resulting DBDCM reagent serves as a basic synthetic unit for the construction of various structurally diverse gem-diborylalkanes through controllable C-Cl functionalizations. Moreover, we have developed consecutive tetra-functionalizations of DBDCM for the construction of diverse tertiary and quaternary carbon containing molecules. The use of isotopically enriched 13 C-chloroform and 10 B2 pin2 enables the synthesis of isotopically enriched 13 C-DBDCM and 10 B-DBDCM reagents, which are beneficial for the convenient synthesis of carbon-13 and boron-10 molecules.