{Reference Type}: Journal Article
{Title}: Prognostic significance of Dickkopf-1 in head and neck squamous cell carcinoma.
{Author}: Chen K;Li J;Ouyang Y;Xie Y;Xu G;Xia T;You R;Liu G;He H;Huang R;Chen M;
{Journal}: Expert Rev Anticancer Ther
{Volume}: 24
{Issue}: 3
{Year}: 2024 Mar-Apr 4
{Factor}: 3.627
{DOI}: 10.1080/14737140.2023.2289597
{Abstract}: <B>UNASSIGNED: </B>Dickkopf-1 (DKK1) exhibits abnormal expression in various cancers and correlates with poor prognosis. This study investigates DKK1's prognostic relevance in head and neck squamous cell carcinoma (HNSC).<BR><B>UNASSIGNED: </B>We conducted a comprehensive search across literature and sequencing databases to gather eligible studies and HNSC datasets. We calculated pooled standardized mean differences (SMD) and 95% confidence intervals (CI) for clinical characteristics, as well as hazard ratios (HR) with 95% CIs for overall survival (OS) and progression-free/disease-free survival (PFS/DFS). Sensitivity analysis gauged result stability, and Egger's test assessed publication bias.<BR><B>UNASSIGNED: </B>Pooled results indicated that HNSC patients with higher T-stage exhibited elevated DKK1 expression levels, and this elevated expression was associated with shorter OS and PFS/DFS. While sensitivity analysis identified some studies significantly affecting pooled results, most were unaffected, and no publication bias was detected.<BR><B>UNASSIGNED: </B>DKK1 holds promise as a potential biomarker for predicting poor prognosis in HNSC patients, but further research is needed for confirmation.