{Reference Type}: Journal Article
{Title}: Autologous point-of-care stromal vascular fraction transplantation in dogs with advanced osteoarthritis of the knee and hip joints.
{Author}: Schroers M;Bruns Y;Waselau AC;Steigmeier-Raith S;Meyer-Lindenberg A;
{Journal}: Aust Vet J
{Volume}: 102
{Issue}: 1
{Year}: 2024 Jan-Feb 4
{Factor}: 1.343
{DOI}: 10.1111/avj.13303
{Abstract}: <B>OBJECTIVE: </B>The aim of the study was to assess lameness in dogs with advanced osteoarthritis of the hip and knee joints after a single autologous point-of-care transplantation of the Stromal Vascular Fraction (SVF) into the affected joint.<BR><B>METHODS: </B>During a minilaparotomy, 10 g of falciform fat was removed from each patient for each joint to be treated. A modern and time-saving procedure (ARC TM System, InGeneron GmbH, Houston, USA) was used for the in-house preparation of the SVF, so that the isolated cells could be applied to the respective joint within 2 h after fat removal. In total, five knee joints of five patients and seven hip joints of four patients were treated.<BR><B>RESULTS: </B>Improvement in lameness according to owner questionnaires was seen in 3 of 5 patients with knee joint arthritis and 2 of 4 patients with hip joint arthritis. Based on gait analysis, only one dog with gonarthrosis and one dog with coxarthrosis showed improvement up to a maximum of 3 months after surgery.<BR><B>CONCLUSIONS: </B>This is the first case series on the treatment of osteoarthrosis of the knee or hip joint using point-of-care transplantation of the SVF. In individual cases, this method may represent a therapeutic approach for the treatment in dogs with advanced cox- or gonarthrosis, although only a short-term effect can be expected, which calls into question the effort and costs involved.