{Reference Type}: Journal Article
{Title}: Tonsil microbiome in pediatric patients with post tonsillectomy hemorrhage for tonsillar hypertrophy.
{Author}: Duan B;Gan M;Xu Z;Chen WX;
{Journal}: Int J Pediatr Otorhinolaryngol
{Volume}: 176
{Issue}: 0
{Year}: 2024 Jan 21
{Factor}: 1.626
{DOI}: 10.1016/j.ijporl.2023.111788
{Abstract}: <B>OBJECTIVE: </B>This study aimed to compare the tonsillar microbiota between post tonsillectomy patients with bleeding and without bleeding, and to investigate the potential role of tonsillar microbiota in the development of post-tonsillectomy hemorrhage (PTH).<BR><B>METHODS: </B>Nineteen tonsillar tissues from PTH patients and 21 tissues from control patients were collected. Metagenomic sequencing was used to compare the microbiota in PTH and control groups. Alpha diversity indices were used to compare the richness and evenness of the microbiota between the two groups. PCoA and NMDS analyses were used to evaluate beta diversity. LDA analysis was conducted to identify significantly abundant genera.<BR><B>RESULTS: </B>No significant difference in alpha diversity indices was found between PTH and control patients. The dominant bacteria in the tonsillar microbiota were Haemophilus, Streptococcus, and Fusobacterium. PCoA and NMDS analyses showed significant differences in beta diversity between PTH and control patients. PTH patients had a significantly higher relative abundance of Neisseria, Capnocytophaga, and Veillonella. Capnocytophaga was also identified as a significantly abundant genus by LDA analysis.<BR><B>CONCLUSIONS: </B>This study demonstrates that there is a difference in the tonsillar microbiota between PTH and control patients. The results suggest that Neisseria, Capnocytophaga, and Veillonella may be associated with the development of PTH. These findings provide new insights into the potential role of the tonsillar microbiota in the development of PTH, and may help to develop new strategies for preventing and treating this potentially life-threatening complication.