{Reference Type}: Meta-Analysis
{Title}: Dynamic changes in ocular shape during human development and its implications for retina fovea formation.
{Author}: Rasys AM;Wegerski A;Trainor PA;Hufnagel RB;Menke DB;Lauderdale JD;
{Journal}: Bioessays
{Volume}: 46
{Issue}: 1
{Year}: 2024 Jan 30
{Factor}: 4.653
{DOI}: 10.1002/bies.202300054
{Abstract}: The human fovea is known for its distinctive pit-like appearance, which results from the displacement of retinal layers superficial to the photoreceptors cells. The photoreceptors are found at high density within the foveal region but not the surrounding retina. Efforts to elucidate the mechanisms responsible for these unique features have ruled out cell death as an explanation for pit formation and changes in cell proliferation as the cause of increased photoreceptor density. These findings have led to speculation that mechanical forces acting within and on the retina during development underly the formation of foveal architecture. Here we review eye morphogenesis and retinal remodeling in human embryonic development. Our meta-analysis of the literature suggests that fovea formation is a protracted process involving dynamic changes in ocular shape that start early and continue throughout most of human embryonic development. From these observations, we propose a new model for fovea development.