{Reference Type}: Journal Article {Title}: Cyclodextrin-based nanosponges as promising carriers for active pharmaceutical ingredient. {Author}: Jawaharlal S;Subramanian S;Palanivel V;Devarajan G;Veerasamy V; {Journal}: J Biochem Mol Toxicol {Volume}: 38 {Issue}: 1 {Year}: 2024 Jan 30 {Factor}: 3.568 {DOI}: 10.1002/jbt.23597 {Abstract}: Effective drug distribution at the intended or particular location is a critical issue that researchers are now dealing. Nanosponges have significantly increased in importance in medication delivery using nanotechnology in recent years. An important step toward solving these problems has been the development of nanosponges. Recently created and proposed for use in drug delivery, nanosponge is a unique type of hyper-crosslinked polymer-based colloidal structures made up of solid nanoparticles with colloidal carriers. Nanosponges are solid porous particles that may hold pharmaceuticals and other actives in their nanocavities. They can be made into dosage forms for oral, parenteral, topical, or inhalation use. The targeted distribution of drugs in a regulated manner is greatly aided by nanosponge. The utilization of nanosponges, their benefits, their production processes, the polymers they are made of, and their characterization have all been covered in this review article.