{Reference Type}: Case Reports {Title}: A massive dentinogenic ghost cell tumor that crossed the midline: A rare case report. {Author}: Sangamithra S;Sukumaran G;Ramani P;Ramasubramanian A;Krishnan RP; {Journal}: J Oral Maxillofac Pathol {Volume}: 27 {Issue}: 3 {Year}: 2023 Jul-Sep 暂无{DOI}: 10.4103/jomfp.jomfp_333_22 {Abstract}: Dentinogenic ghost cell tumor (DGCT) is a rare tumor of odontogenic origin. A locally invasive lesion can be described by the presence of ameloblast-like epithelial islands, ghost cells, and dentinoid material. It is one of the few lesions with a predilection for the Asian population. The available literature has revealed that only 131 cases to date have been reported and published from 1968 to 2022. The following is a case report of a 25-year-old male with a tumor in the left lower back teeth region for the past 1 month. Orthopantomogram (OPG) reveals a well-defined unilocular radiolucency extending anteroposteriorly and crossing the midline. Histopathology revealed basal ameloblast-like cells and central stellate reticulum-like cells with the characteristic presence of ghost cells. The diagnosis was made based on the clinical, radiographical, and histopathological correlation and was confirmed using immunohistochemical analysis as a DGCT.