{Reference Type}: Journal Article {Title}: Mechanisms by which microbial enzymes degrade four mycotoxins and application in animal production: A review. {Author}: Sun H;He Z;Xiong D;Long M; {Journal}: Anim Nutr {Volume}: 15 {Issue}: 0 {Year}: 2023 Dec {Factor}: 5.285 {DOI}: 10.1016/j.aninu.2023.09.003 {Abstract}: Mycotoxins are toxic compounds that pose a serious threat to animal health and food safety. Therefore, there is an urgent need for safe and efficient methods of detoxifying mycotoxins. As biotechnology has continued to develop, methods involving biological enzymes have shown great promise. Biological enzymatic methods, which can fundamentally destroy the structures of mycotoxins and produce degradation products whose toxicity is greatly reduced, are generally more specific, efficient, and environmentally friendly. Mycotoxin-degrading enzymes can thus facilitate the safe and effective detoxification of mycotoxins which gives them a huge advantage over other methods. This article summarizes the newly discovered degrading enzymes that can degrade four common mycotoxins (aflatoxins, zearalenone, deoxynivalenol, and ochratoxin A) in the past five years, and reveals the degradation mechanism of degrading enzymes on four mycotoxins, as well as their positive effects on animal production. This review will provide a theoretical basis for the safe treatment of mycotoxins by using biological enzyme technology.