{Reference Type}: Journal Article
{Title}: SHEAR saliva collection device augments sample properties for improved analytical performance.
{Author}: Song SW;Gupta R;Jothilingam N;Qian X;Gu Y;Lee VV;Sapanel Y;Allen DM;Wong JEL;MacAry P;Ho D;Blasiak A;
{Journal}: Bioeng Transl Med
{Volume}: 8
{Issue}: 6
{Year}: 2023 Nov
{Factor}: 10.684
{DOI}: 10.1002/btm2.10490
{Abstract}: Despite being a convenient clinical substrate for biomonitoring, saliva's widespread utilization has not yet been realized. The non-Newtonian, heterogenous, and highly viscous nature of saliva complicate the development of automated fluid handling processes that are vital for accurate diagnoses. Furthermore, conventional saliva processing methods are resource and/or time intensive precluding certain testing capabilities, with these challenges aggravated during a pandemic. The conventional approaches may also alter analyte structure, reducing application opportunities in point-of-care diagnostics. To overcome these challenges, we introduce the SHEAR saliva collection device that mechanically processes saliva, in a rapid and resource-efficient way. We demonstrate the device's impact on reducing saliva's viscosity, improving sample's uniformity, and increasing diagnostic performance of a COVID-19 rapid antigen test. Additionally, a formal user experience study revealed generally positive comments. SHEAR saliva collection device may support realization of the saliva's potential, particularly in large-scale and/or resource-limited settings for global and community diagnostics.