{Reference Type}: Review
{Title}: Long-Smoldering T-prolymphocytic Leukemia: A Case Report and a Review of the Literature.
{Author}: Gjelberg HK;Helgeland L;Liseth K;Micci F;Sandnes M;Russnes HG;Reikvam H;
{Journal}: Curr Oncol
{Volume}: 30
{Issue}: 11
{Year}: 2023 11 18
{Factor}: 3.109
{DOI}: 10.3390/curroncol30110727
{Abstract}: T-prolymphocytic leukemia (T-PLL) is a rare malignancy of mature T-cells with distinct clinical, cytomorphological, and molecular genetic features. The disease typically presents at an advanced stage, with marked leukocytosis, B symptoms, hepatosplenomegaly, and bone marrow failure. It usually follows an aggressive course from presentation, and the prognosis is often considered dismal; the median overall survival is less than one year with conventional chemotherapy. This case report describes a patient with T-PLL who, after an unusually protracted inactive phase, ultimately progressed to a highly invasive, organ-involving disease. After initial treatments failed, a novel treatment approach resulted in a significant response.