{Reference Type}: Case Reports
{Title}: Facial-onset sensory and motor neuronopathy with myasthenia gravis: A case report.
{Author}: Pan C;Yang X;Tai Z;Zhou Z;Hao R;Wang J;Liang T;
{Journal}: Medicine (Baltimore)
{Volume}: 102
{Issue}: 46
{Year}: 2023 Nov 17
{Factor}: 1.817
{DOI}: 10.1097/MD.0000000000034215
{Abstract}: <B>BACKGROUND: </B>Facial-onset sensory and motor neuronopathy (FOSMN) is a greatly rare disease, so far, autopsy evidence that is associated with neurodegenerative. Myasthenia gravis (MG) is an antibody-mediated and complement-involved acquired autoimmune disorder of the post-synaptic neuromuscular junction. There have been few reports about if there is related between the 2. In this study, we present the case of a man who was diagnosed as FOSMN with MG in continuity.<BR><B>METHODS: </B>The patient chief complaints were right-side facial numbness and right-eyelid incomplete closure, followed by slurred speech and dysphagia, and the symptoms gradually progressed. The patient serum was positive for anti-AchR and anti-Titin antibodies.<BR><B>METHODS: </B>The patient was diagnosed FOSMN with MG.<BR><B>METHODS: </B>The patient symptoms were relieved after pyridostigmine bromide and prednisolone treatment.<BR><B>RESULTS: </B>Symptoms have improved.<BR><B>CONCLUSIONS: </B>Facial-onset sensory and motor neuronopathy and MG have disparate clinical features. Therefore, we reported a rare case in which the 2 conditions concurrently existed. Immune dysfunction might be the pathogenesis of this association, while there is no definite evidence to support it, further studies are needed.