{Reference Type}: Journal Article
{Title}: Kueishanamides A and B from the Hydrothermal Vent Sediment Derived Streptomyces sp. WU20.
{Author}: Ge Y;Ma Y;Zhou C;Zhang Z;Yin Q;Zhang X;Zhang Z;Wu B;
{Journal}: Chem Biodivers
{Volume}: 20
{Issue}: 12
{Year}: 2023 Dec 20
{Factor}: 2.745
{DOI}: 10.1002/cbdv.202301345
{Abstract}: Marine actinomycetes are known for their production of remarkable organic molecules, particularly those featuring polyoxygenated long-chain backbones. Determining the absolute configurations of these compounds remains a challenging task even today. In this study, we successfully established the planar structures and absolute configurations of two highly flexible amide alkaloids from Streptomyces sp. WU20: kueishanamides A (1) and B (2). These compounds possess a C13 linear backbone and each contains five stereogenic carbon centers. Our approach involved a combination of spectroscopic and computational methods, including J-based configurational analysis and VCD calculations, ensuring the unambiguous determination of their configurations. Kueishanamide A (1) and kueishanamide B (2) showed moderate antifungal activity against pathogenic fungus Crytococcus neoformans, with MIC values of 25 μg/mL each.