{Reference Type}: Journal Article
{Title}: A novel ultrasensitive assay for plasma p-tau217: Performance in individuals with subjective cognitive decline and early Alzheimer's disease.
{Author}: Gonzalez-Ortiz F;Ferreira PCL;González-Escalante A;Montoliu-Gaya L;Ortiz-Romero P;Kac PR;Turton M;Kvartsberg H;Ashton NJ;Zetterberg H;Harrison P;Bellaver B;Povala G;Villemagne VL;Pascoal TA;Ganguli M;Cohen AD;Minguillon C;Contador J;Suárez-Calvet M;Karikari TK;Blennow K;
{Journal}: Alzheimers Dement
{Volume}: 20
{Issue}: 2
{Year}: 2024 02 17
{Factor}: 16.655
{DOI}: 10.1002/alz.13525
{Abstract}: Detection of Alzheimer's disease (AD) pathophysiology among individuals with mild cognitive changes and those experiencing subjective cognitive decline (SCD) remains challenging. Plasma phosphorylated tau 217 (p-tau217) is one of the most promising of the emerging biomarkers for AD. However, accessible methods are limited.<BR>We employed a novel p-tau217 immunoassay (University of Gothenburg [UGOT] p-tau217) in four independent cohorts (n = 308) including a cerebrospinal fluid (CSF) biomarker-classified cohort (Discovery), two cohorts consisting mostly of cognitively unimpaired (CU) and mild cognitively impaired (MCI) participants (MYHAT and Pittsburgh), and a population-based cohort of individuals with SCD (Barcelonaβeta Brain Research Center's Alzheimer's At-Risk Cohort [β-AARC]).<BR>UGOT p-tau217 showed high accuracy (area under the curve [AUC] = 0.80-0.91) identifying amyloid beta (Aβ) pathology, determined either by Aβ positron emission tomography or CSF Aβ42/40 ratio. In individuals experiencing SCD, UGOT p-tau217 showed high accuracy identifying those with a positive CSF Aβ42/40 ratio (AUC = 0.91).<BR>UGOT p-tau217 can be an easily accessible and efficient way to screen and monitor patients with suspected AD pathophysiology, even in the early stages of the continuum.