{Reference Type}: Editorial {Title}: The Intriguing Sigma-1 and Sigma-2 Receptors and Their Potential Therapeutic Roles 2.0. {Author}: Abate C;Maurice T; {Journal}: Int J Mol Sci {Volume}: 24 {Issue}: 21 {Year}: 2023 Nov 1 {Factor}: 6.208 {DOI}: 10.3390/ijms242115868 {Abstract}: For some time now, the research on sigma receptors has been at a high level of maturity but, despite everything that has already been achieved, further work in this field still holds huge appeal, with vast possibilities for original discoveries [...].