{Reference Type}: Meta-Analysis
{Title}: Pediatric ocular melanoma: a collaborative multicenter study and meta-analysis.
{Author}: Masoomian B;Dalvin LA;Riazi-Esfahani H;Ghassemi F;Azizkhani M;Mirghorbani M;Khorrami-Nejad M;Sajjadi Z;Kaliki S;Sagoo MS;Al Harby L;Al-Jamal RT;Kivelä TT;Giblin M;Lim LS;Shields CL;
{Journal}: J AAPOS
{Volume}: 27
{Issue}: 6
{Year}: 2023 12 8
{Factor}: 1.325
{DOI}: 10.1016/j.jaapos.2023.08.021
{Abstract}: To investigate clinical manifestations and prognoses in pediatric patients (≤12 years old) with ocular melanoma.<BR>This was a retrospective, multicenter cohort study with individual participant data (IPD) meta-analysis pooling available published cases, and unpublished cases from an international collaboration of seven ocular oncology centers.<BR>There were 133 eyes of 133 pediatric patients with choroidal or ciliary body (n = 66 [50%]), iris (n = 33 [25%]), conjunctival (n = 26 [19%]), and eyelid (n = 8 [6%]) melanoma. Overall, the mean patient age at presentation was 7 years (median, 8; range, 1-12 years), with 63 males (49%). The mean age by tumor site was 6.50 ± 3.90, 7.44 ± 3.57, 9.12 ± 2.61, and 5.63 ± 2.38 years, for choroid/ciliary body, iris, conjunctiva, and eyelid melanoma, respectively (P = 0.001). Association with ocular melanocytosis was seen in 15%, 11%, 4%, and 0%, respectively (P = 0.01). Frequency of ocular melanoma family history did not vary by tumor site (7%, 17%, 9% and 12%, resp. [P = 0.26]). After mean follow-up of 74, 85, 50, and 105 months (P = 0.65), metastasis was seen in 12%, 9%, 19%, and 13% of choroid/ciliary body, iris, conjunctiva, and eyelid melanoma, respectively. Death was reported in 5%, 3%, 8%, and 0%, respectively, with survival analysis indicating higher mortality in choroidal/ciliary body and conjunctival melanoma patients.<BR>Ocular melanoma in the pediatric population is rare, with unique clinical features and outcomes. Iris melanoma accounts for about one-third of pediatric uveal melanoma cases.