{Reference Type}: Journal Article
{Title}: Fitostimoline® in fibro-endoscopic and trans-nasal trans-speculum septoplasty as a beneficial tool to improve post-surgical outcome: Preliminary results of a case-control study.
{Author}: De Luca P;La Mantia I;Gioacchini FM;Re M;Radici M;Camaioni A;Di Stadio A;
{Journal}: Am J Otolaryngol
{Volume}: 45
{Issue}: 1
{Year}: 2024 Jan-Feb 3
{Factor}: 2.873
{DOI}: 10.1016/j.amjoto.2023.104107
{Abstract}: <B>OBJECTIVE: </B>Topic treatment can be useful to improve short and long-term nasal outcomes after nasal surgery, reducing discomfort and risk of synechia. This study aimed at evaluating the effect on clinical outcomes of nasal packaging using Fitostimoline® gauze in FESS and septoplasty.<BR><B>METHODS: </B>A case-control study on hospitalized patients was performed in a tertiary referral center. The control group included 20 patients treated with the standard surgical protocol for septoplasty and standard nasal packaging; treatment group included 21 patients underwent same surgical procedure but in whom the nasal tampon was wrapped with a gauze containing Fitostimoline® before being placed into the nose.<BR><B>RESULTS: </B>Patients in treatment group had better outcomes than control; nasal mucosa showed better healing - recovery of normal color- in those patients in whom we applied the Fitostimoline® gauze around tampons. Moreover, 100 % patients in the treatment group did not refer discomfort during at tampon removal versus 60 % subjects in the control group who referred pain, tension or tearing during the same action.<BR><B>CONCLUSIONS: </B>Our results, although preliminary because of the small cohort of subjects included, suggest that the apposition of a gauze with Fitostimoline® after nasal surgery might improve the mucosal healing with consequent reduction of patients discomfort during the post-surgical period.