{Reference Type}: Journal Article
{Title}: Viral lumbosacral radiculitis (Elsberg syndrome) in Denmark.
{Author}: Petersen PT;Bodilsen J;Jepsen MPG;Larsen L;Storgaard M;Hansen BR;Lüttichau HR;Helweg-Larsen J;Wiese L;Andersen CØ;Nielsen H;Brandt CT; ;
{Journal}: Infection
{Volume}: 52
{Issue}: 3
{Year}: 2024 Jun 2
{Factor}: 7.455
{DOI}: 10.1007/s15010-023-02113-9
{Abstract}: <B>OBJECTIVE: </B>To describe clinical features and outcomes of viral lumbosacral radiculitis (Elsberg syndrome).<BR><B>METHODS: </B>Nationwide population-based cohort study of all adults hospitalised for viral lumbosacral radiculitis at departments of infectious diseases in Denmark from 2015 to 2020.<BR><B>RESULTS: </B>Twenty-eight patients with viral lumbosacral radiculitis were included (mean annual incidence: 1.2/1,000,000 adults). The median age was 35 years (IQR 27-43), and 22/28 (79%) were female. All patients had urinary retention, with 17/28 (61%) needing a catheter. On admission, at least one sign or symptom of meningitis (headache, neck stiffness, photophobia/hyperacusis) was present in 18/22 (82%). Concurrent genital herpetic lesions were present in 11/24 (46%). The median cerebrospinal fluid leukocyte count was 153 cells/µL (IQR 31-514). Magnetic resonance imaging showed radiculitis/myelitis in 5/19 (26%). The microbiological diagnosis was herpes simplex virus type 2 in 19/28 (68%), varicella-zoster virus in 2/28 (7%), and unidentified in 7/28 (25%). Aciclovir/valaciclovir was administered in 27/28 (96%). At 30 days after discharge, 3/27 (11%) had persistent urinary retention with need of catheter. At 180 days after discharge, moderate disabilities (Glasgow Outcome Scale score of 4) were observed in 5/25 (20%).<BR><B>CONCLUSIONS: </B>Urinary retention resolved within weeks in most patients with viral lumbosacral radiculitis, but moderate disabilities according to the Glasgow Outcome Scale were common at the end of follow-up.