{Reference Type}: Journal Article
{Title}: Systemic sclerosis sine scleroderma with atypical clinical course: a rare case report.
{Author}: Samha R;Ghaddar SA;Raya M;Alhadi SA;
{Journal}: Ann Med Surg (Lond)
{Volume}: 85
{Issue}: 11
{Year}: 2023 Nov
暂无{DOI}: 10.1097/MS9.0000000000001266
{Abstract}: <B>UNASSIGNED: </B>Systemic sclerosis (SSc) is divided into three subtypes: limited cutaneous SSc (lcSSc), diffuse cutaneous SSc (dcSSc), and systemic sclerosis sine scleroderma (ssSSc). ssSSc is a rare subtype of SSc that presents with internal organ manifestations but no cutaneous findings.<BR><B>UNASSIGNED: </B>We report the case of a 58-year-old patient with a history of pulmonary hypertension who presented with symptoms of fatigue, inflammatory polyarthritis, and joint swelling. Following a comprehensive clinical examination and laboratory tests, the patient was diagnosed with ssSSc.<BR><B>UNASSIGNED: </B>Due to its atypical clinical course, we present this case report, which commenced with idiopathic pulmonary hypertension. Subsequently, after 7 months, the patient presented complaints of polyarthritis with positive antinuclear antibodies. Raynaud's phenomenon was identified 2 months later during the rheumatology clinic examination. Typically, the clinical course encompasses all three features simultaneously, without any gap between them.<BR><B>UNASSIGNED: </B>Diagnosis of ssSSc remains challenging, and it is essential to consider this disease form in all cases involving unexplained fibrotic involvement of the internal organs.