{Reference Type}: Journal Article
{Title}: Reperfusion of retinal nonperfusion by neovascular-vascular anastomosis in proliferative diabetic retinopathy.
{Author}: Shiraki A;Tsuboi K;Wakabayashi T;Shiraki N;Nishida K;
{Journal}: Eur J Ophthalmol
{Volume}: 34
{Issue}: 2
{Year}: 2024 Mar 1
{Factor}: 1.922
{DOI}: 10.1177/11206721231210896
{Abstract}: <B>BACKGROUND: </B>Retinal nonperfusion is a significant cause of vision loss in patients with proliferative diabetic retinopathy (PDR). Therefore, reperfusion of a nonperfusion has been a matter of strong interest, but few previous studies have demonstrated the potential benefits of reperfusion.<BR><B>METHODS: </B>Here, we report longitudinal optical coherence tomography angiographic analysis of two cases of PDR, in which the retinal neovascularization (RNV) that developed in response to retinal ischemia formed anastomoses with pre-existing physiological retinal vessels, resulting in both superficial and deep capillary reperfusion within the nonperfusion. We named this interesting finding "neovascular-vascular anastomosis." Retinal reperfusion due to neovascular-vascular anastomosis differed from recanalization, defined as reperfusion of once-occluded blood vessels, and has not been reported previously.<BR><B>CONCLUSIONS: </B>Our observation highlights the potential of RNV to rescue retinal ischemia by the formation of neovascular-vascular anastomoses.