{Reference Type}: Journal Article {Title}: A Prospective Study on the Impact of Clinical Factors and Adjusted Triple D System for Success Rate of ESWL. {Author}: Snicorius M;Drevinskaitė M;Miglinas M;Čekauskas A;Urbonienė V;Bandzevičiūtė R;Čeponkus J;Šablinskas V;Želvys A; {Journal}: Medicina (Kaunas) {Volume}: 59 {Issue}: 10 {Year}: 2023 Oct 13 {Factor}: 2.948 {DOI}: 10.3390/medicina59101827 {Abstract}: Objective: Our study aimed to evaluate the success rate of ESWL and identify relevant treatment-specific factors affecting treatment outcomes, as well as to assess the accuracy of the updated Triple D scoring system and compare it with older systems. Material and Methods: A prospective study of 71 patients who received ESWL treatment for renal stones that were 5-15 mm in size was completed. The patient having no residual stones or residual stones lesser than 4 mm after ESWL was identified as a treatment success. Univariate and multivariate logistic regression and ROC curves were used to identify important factors for treatment outcomes. Results: Successful treatment was achieved for 66.2% of patients. The stone volume (SV), mean stone density (MD), and delivered power to the stone volume unit ratio (SMLI/SV) were defined as the most critical factors influencing ESWL success. An updated Triple D score system with a, SMLI/SV ratio could be an alternative to older systems and reach an even higher accuracy. A limitation of this study is the limited sample size due to the COVID-19 pandemic. Conclusions: Our results show that the three factors that most influence the success of ESWL are the stone size, mean stone density, and SMLI/SV ratio. Based on this, we present a simple updated triple D score system to predict ESWL success, which could be implemented in future clinical practice.