{Reference Type}: Journal Article
{Title}: Biological therapy, surgery, and hospitalization rates for inflammatory bowel disease: An observational Latin American comparative study between adults and pediatric patients.
{Author}: Silva ACV;Tumelero TJ;Yamamoto DR;Truppel SK;da Silva GS;Ribeiro LBM;Zacharias P;Olandoski M;Magro DO;Vieira MC;Kotze PG;
{Journal}: Gastroenterol Hepatol
{Volume}: 0
{Issue}: 0
{Year}: 2023 Oct 26
{Factor}: 5.867
{DOI}: 10.1016/j.gastrohep.2023.10.006
{Abstract}: <B>OBJECTIVE: </B>Compare the proportions of use of biological therapy, surgeries, and hospitalizations between adults and pediatric inflammatory bowel disease (IBD)-Crohn's disease (CD) and ulcerative colitis (UC)-patients.<BR><B>METHODS: </B>Observational, retrospective, and multicenter study. Data were collected from all consecutive IBD patients seen as outpatients or admitted to hospital, during 2015-2021, in two IBD tertiary centers in a South Brazilian capital. Patients with unclassified colitis diagnosis were excluded from this study. Patients were classified as having CD or UC and sub-categorized as adult or pediatric according to age. Data were analyzed using frequency, proportion, Fisher's exact test, and Chi-square test.<BR><B>RESULTS: </B>A total of 829 patients were included: 509 with CD (378 adults/131 pediatric) and 320 with UC (225/95). Among patients with CD, no differences were observed for proportions of use of biological therapy (80.2% in pediatric vs. 73.3% in adults; P=0.129), surgery (46.6% vs. 50.8%; P=0.419), or hospitalization (64.9% vs. 56.9%; P=0.122). In UC, significant differences were observed for biological therapy (40.0% vs. 28.0%; P=0.048) and hospitalization (47.4% vs. 24.0%; P<0.001). No significant difference was observed in surgery rates (17.9% vs. 12.4%; P=0.219).<BR><B>CONCLUSIONS: </B>Biological therapy and incidence of hospitalization were greater among pediatric patients with UC, compared with adults; no difference was observed in the need for abdominal surgery. In CD, no significant difference was observed in the three main outcomes between the age groups.