{Reference Type}: Journal Article
{Title}: Making normal hematopoiesis invisible to CAR T cells.
{Author}: Kim MY;
{Journal}: Trends Cancer
{Volume}: 9
{Issue}: 12
{Year}: 2023 12 18
{Factor}: 19.161
{DOI}: 10.1016/j.trecan.2023.10.001
{Abstract}: Two recent studies, by Casirati et al. and Wellhausen et al., report genetically engineering normal hematopoietic stem and progenitor cells (HSPCs) to be resistant to chimeric antigen receptor (CAR)-T cells, by changing a single amino acid in the target protein that abrogates CAR binding, without compromising protein function. This allows for selective targeting of cancer cells without harming normal hematopoietic cells.