{Reference Type}: Journal Article
{Title}: Retrospective Analysis of Death Cases of Oral Diphenidol Hydrochloride Poisoning.
{Author}: Yang Y;Lei FZ;Dong YY;Ma JL;Shi QQ;Ye XS;
{Journal}: Fa Yi Xue Za Zhi
{Volume}: 39
{Issue}: 4
{Year}: 2023 Aug 25
暂无{DOI}: 10.12116/j.issn.1004-5619.2022.420401
{Abstract}: <B>OBJECTIVE: </B>To explore the characteristics of postmortem examination, chemical examination and scene investigation of deaths caused by oral diphenidol hydrochloride poisoning, and so as to provide a reference for proper settlement and prevention of such deaths.<BR><B>METHODS: </B>The data of 22 deaths caused by oral diphenidol hydrochloride poisoning in a city from January 2018 to August 2020 were collected, including case details, scene investigations, autopsies, chemical examinations and digital evidence. Thirty-one cases of deaths caused by oral diphenidol hydrochloride poisoning reported in previous literature were also collected.<BR><B>RESULTS: </B>In the 53 oral diphenidol hydrochloride poisoning death cases, 50 cases were suicide, 2 cases were accidental, while 1 case was undetermined. Fifty-two cases were found in the medical records or crime scene investigation reports with doses ranging from 775 mg to 12 500 mg, and 23 deceased were detected with postmortem blood concentrations ranging from 2.71 mg/L to 83.1 mg/L. Clinical symptoms were recorded in 6 patients, including conscious disturbance and convulsion. Among the 45 cases which were performed with external examination, 23 cases autopsied.<BR><B>CONCLUSIONS: </B>Most of the deceased of oral diphenidol hydrochloride poisoning were suicide. No significant correlation was found between dose and blood concentration through the retrospective analysis of cases.<BR>目的: 探讨口服盐酸地芬尼多中毒死亡案例的尸体检验、理化检验和现场勘验特点，为相关案（事）件的处置和预防提供参考。方法: 收集某市2018年1月—2020年8月发生的22例口服盐酸地芬尼多中毒死亡案例的案情、现场勘验、尸体检验、理化检验、电子物证等资料，结合既往文献报道的31例口服盐酸地芬尼多中毒死亡案例进行分析。结果: 53例口服盐酸地芬尼多中毒死亡案例中，50例为自杀，2例为意外，1例性质不详。52例在病历记录或现场勘验记录中找到服药剂量，范围为775~12 500 mg。有服药剂量的52例中，23例经死后药物浓度检测，血药质量浓度范围为2.71~83.1 mg/L。记录有临床症状的6例，表现为意识障碍、抽搐。经尸表检查的45例中，有23例进行了尸体解剖。结论: 口服盐酸地芬尼多中毒死者多数为自杀。通过多个案例的回顾性分析，尚未发现服药剂量与血药浓度之间具有相关性。.