{Reference Type}: English Abstract
{Title}: [Correlation of mycoplasma genitalium infection with sperm DNA fragmentation in male infertility patients].
{Author}: Zheng Q;Zhong Y;
{Journal}: Zhonghua Nan Ke Xue
{Volume}: 28
{Issue}: 11
{Year}: 2022 Nov
暂无{Abstract}: <B>OBJECTIVE: </B>To study the impact of mycoplasma genitalium (Mg) infection on sperm DNA fragmentation in male infertility patients and its clinical significance.<BR><B>METHODS: </B>We performed flow cytometry and routine semen examination for 100 male infertility patients with Mg infection (the case group) and 200 infertile men without Mg infection (the control group). We treated the patients with the antibacterial drug Azithromycin and examined their sperm DNA fragmentation index (DFI) by flow cytometry after treatment.<BR><B>RESULTS: </B>The baseline sperm DFI was dramatically higher in the case group than in the normal controls (［40.1 ± 9.9］% vs ［5.4 ± 4.9］%, (P < 0.01), but reduced to (19.0 ± 9.0)% after antibacterial medication (P < 0.01). The count of immotile sperm was significantly decreased in the infertility patients after treatment (P < 0.05), but no statistically significant difference was observed in sperm concentration and motility before and after treatment (P > 0.05).<BR><B>CONCLUSIONS: </B>The sperm DFI is significantly higher in male infertility patients with Mg infection than in normal men, and antibacterial therapy can effectively reduce the level of Mg infection-induced sperm DNA fragmentation. The analysis of sperm DNA fragmentation plays a more significant role than routine semen examination in the diagnosis and treatment of male infertility with Mg infection.