{Reference Type}: Journal Article
{Title}: The role of APOBEC3-induced mutations in the differential evolution of monkeypox virus.
{Author}: Li X;Habibipour S;Chou T;Yang OO;
{Journal}: Virus Evol
{Volume}: 9
{Issue}: 2
{Year}: 2023
{Factor}: 5.614
{DOI}: 10.1093/ve/vead058
{Abstract}: Recent studies show that newly sampled monkeypox virus (MPXV) genomes exhibit mutations consistent with Apolipoprotein B mRNA Editing Catalytic Polypeptide-like3 (APOBEC3)-mediated editing compared to MPXV genomes collected earlier. It is unclear whether these single-nucleotide polymorphisms (SNPs) result from APOBEC3-induced editing or are a consequence of genetic drift within one or more MPXV animal reservoirs. We develop a simple method based on a generalization of the General-Time-Reversible model to show that the observed SNPs are likely the result of APOBEC3-induced editing. The statistical features allow us to extract lineage information and estimate evolutionary events.