{Reference Type}: Case Reports {Title}: Large mesenchymal cystic and chondroid pulmonary hamartoma mimicking lung cancer: Case report. {Author}: Ahn S;Lee H;Kang JK;Kim IS;Moon Y;Choi JS;Choi SY; {Journal}: J Cardiothorac Surg {Volume}: 18 {Issue}: 1 {Year}: 2023 Oct 10 {Factor}: 1.522 {DOI}: 10.1186/s13019-023-02394-z {Abstract}: Pulmonary hamartoma is the most commonly resected benign neoplasm of lung. The mesenchymal cystic subtype is a rare and often bilaterally occurring variant composed of multiple cysts and nodules. Herein, we present an asymptomatic 70-year-old woman with a large and mostly cystic growth of right hilar region. Computed tomography of the chest and fluorodeoxyglucose positron emission tomography/computed tomography imaging traced its origins to right middle lobe. Overall features suggested primary lung cancer or perhaps other cystic lung disease.Because transbronchial lung biopsy failed to establish a histologic diagnosis, right middle lobectomy was undertaken by video-assisted thoracoscopic surgery. The gross surgical specimen harbored a single and sizeable (8.0 × 4.0 cm) cystic lesion containing multiple yellow-white nodules. A diagnosis of mesenchymal cystic and chondroid hamartoma was ultimately rendered. This particular case is noteworthy, given the initial clinical resemblance to primary lung cancer.