{Reference Type}: Case Reports
{Title}: Small intestinal adenocarcinoma accompanied by lynch syndrome: A case report.
{Author}: Yoon KW;Jo J;Lee D;
{Journal}: Medicine (Baltimore)
{Volume}: 102
{Issue}: 39
{Year}: 2023 Sep 29
{Factor}: 1.817
{DOI}: 10.1097/MD.0000000000035323
{Abstract}: <B>BACKGROUND: </B>Lynch syndrome is caused by germline mutations of DNA mismatch repair genes. A significant risk increase for several types of cancer is one of the characteristics of lynch syndrome.<BR><B>METHODS: </B>A 45-year-old female presented to the emergency department with abdominal pain that had persisted for a month.<BR><B>METHODS: </B>The abdominal and pelvic computed tomography scan showed edematous and thickening of the proximal small bowel wall, as well as dilatation of the proximal bowel and stomach.<BR><B>METHODS: </B>Tumor resection of the small bowel was performed, and adenocarcinoma was confirmed pathologically. Microsatellite instability was also confirmed.<BR><B>RESULTS: </B>Postoperative imaging revealed soft tissue lesions with potential for tumor seeding. Two months after the first surgery, a secondary surgery was performed as a result of cancer recurrence. The patient received chemotherapy with capecitabine. The latest computed tomography scan, performed 19 months after the cessation of chemotherapy, did not show any recurrence.<BR><B>CONCLUSIONS: </B>In the rare incidence of small bowel cancer genetic mutation testing and detailed family history should be actively considered.