{Reference Type}: Journal Article
{Title}: Treatment Modality Impact on Patient-Reported Quality of Life in Human Papilloma Virus-Associated Oropharyngeal Carcinoma.
{Author}: Plonowska-Hirschfeld KA;Gulati A;Stephens EM;Ochoa E;Xu MJ;Ha PK;Heaton CM;Yom SS;Chan JW;Algazi A;Kang H;Ryan WR;
{Journal}: Laryngoscope
{Volume}: 134
{Issue}: 4
{Year}: 2024 Apr 28
{Factor}: 2.97
{DOI}: 10.1002/lary.31065
{Abstract}: <B>OBJECTIVE: </B>To prospectively compare the impact of treatment modality on patient-reported quality of life (QOL) in human papillomavirus-associated oropharynx squamous cell carcinoma (HPV + OPSCC).<BR><B>METHODS: </B>Prospective cohort study.<BR><B>METHODS: </B>Academic medical center.<BR><B>METHODS: </B>One hundred one patients with American Joint Committee on Cancer (AJCC) 8th edition T1-3 N0-2 HPV + OPSCC completed the European Organization for Research and Treatment of Cancer Quality of Life Core questionnaire and Head and Neck Module pretreatment and 3-month and 1-year posttreatment. Mean score changes were compared to published minimal clinically important differences.<BR><B>RESULTS: </B>Patients underwent surgery alone (SA: N = 42, 42%), surgery with adjuvant radiation (S-RT: N = 10, 10%), surgery with adjuvant chemoradiation (S-CRT: N = 8, 8%), definitive radiation (RT: N = 11, 11%), or definitive chemoradiation (CRT: N = 30, 30%). SA, S-[C]RT, and [C]RT patients all reported clinically significant difficulty with sense of taste/smell persisting at 1 year. S-[C]RT and [C]RT patients reported statistically and clinically significant worse salivary dysfunction and problems with social eating at 1 year than SA. S-[C]RT patients reported statistically and clinically significant worse fatigue and head and neck pain compared to [C]RT and SA patients at 3 months, but normalized at 1 year. S-CRT compared to S-RT had statistically and clinically worse physical and role functioning and swallowing difficulties at 3 months but this difference was resolved by 1-year posttreatment.<BR><B>CONCLUSIONS: </B>HPV + OPSCC patients after SA report the lowest posttreatment QOL impact, whereas after S-CRT report the highest symptom burden. Careful selection for definitive surgery is important given the possibility of adjuvant CRT. Patients can experience persistent sense taste and smell difficulties at 1 year with all treatment modalities.<BR><B>METHODS: </B>3 Laryngoscope, 134:1687-1695, 2024.