{Reference Type}: Journal Article
{Title}: Cathepsin C role in inflammatory gastroenterological, renal, rheumatic, and pulmonary disorders.
{Author}: Aghdassi AA;Pham C;Zierke L;Mariaule V;Korkmaz B;Rhimi M;
{Journal}: Biochimie
{Volume}: 216
{Issue}: 0
{Year}: 2024 Jan 26
{Factor}: 4.372
{DOI}: 10.1016/j.biochi.2023.09.018
{Abstract}: Cathepsin C (CatC, syn. Dipeptidyl peptidase I) is a lysosomal cysteine proteinase expressed in several tissues including inflammatory cells. This enzyme is important for maintaining multiple cellular functions and for processing immune cell-derived proteases. While mutations in the CatC gene were reported in Papillon-Lefèvre syndrome, a rare autosomal recessive disorder featuring hyperkeratosis and periodontitis, evidence from clinical and preclinical studies points toward pro-inflammatory effects of CatC in various disease processes that are mainly mediated by the activation of neutrophil serine proteinases. Moreover, tumor-promoting effects were ascribed to CatC. The aim of this review is to highlight current knowledge of the CatC as a potential therapeutic target in inflammatory disorders.