{Reference Type}: Journal Article
{Title}: Bradykinin deficiency causes high blood pressure in mice.
{Author}: Ohnaka Y;Tsukamoto S;Iwai Y;Hamada-Kanazawa M;Kariya R;Takano M;
{Journal}: Biochem Biophys Res Commun
{Volume}: 681
{Issue}: 0
{Year}: 2023 11 12
{Factor}: 3.322
{DOI}: 10.1016/j.bbrc.2023.09.059
{Abstract}: Bradykinin has a wide variety of physiological functions, including vasodilation and blood pressure reduction. However, the physiological roles of bradykinin are not fully understood. We used the CRISPR/Cas9 method to generate BKdelK1 and BKdelK2 mutant mice, targeting the BK portion of mouse kininogen1 and kininogen2 genes, respectively. The BKdelK1 and BKdelK2 mutant mice had about 50% reductions in plasma low molecular weight kininogen and trypsin-released BK, compared to wild mice. Both BKdelK1 and BKdelK2 mice had significantly elevated systolic blood pressure compared to WT mice. These results suggest that plasma LKNG is a source of KNG in the vascular kallikrein-kinin system and contributes to maintaining lower systolic blood pressure.