{Reference Type}: Journal Article
{Title}: β-glucuronidase as a biomarker for assessing the exposure to anticholinergic pesticides: A meta-analysis.
{Author}: Serafín-Fabian JI;Elena Moreno-Godínez M;Flores-Alfaro E;Parra-Rojas I;Rojas-García AE;Campos-Viguri GE;Cahua-Pablo JÁ;Ramírez-Vargas MA;
{Journal}: Environ Toxicol Pharmacol
{Volume}: 103
{Issue}: 0
{Year}: 2023 Oct 21
{Factor}: 5.785
{DOI}: 10.1016/j.etap.2023.104279
{Abstract}: <B>BACKGROUND: </B>The human exposure to anticholinergic pesticides has been associated with the development of various diseases. Therefore, several biomarkers have been proposed for biomonitoring human exposure to anticholinergic pesticides.<BR><B>OBJECTIVE: </B>This work evaluated the effect of human exposure to anticholinergic pesticides on β-glucuronidase (GUSB) levels.<BR><B>METHODS: </B>A systematic review was performed using PubMed, Web of Science, Scopus, and EBSCO databases up to December 2021. The statistical analysis employed standardized mean differences and meta-regression. And the trial sequential analysis was performed.<BR><B>RESULTS: </B>Nine studies were included. A monotonic relationship was observed between poisoning severity and GUSB. Furthermore, BuChE levels were correlated with GUSB levels.<BR><B>CONCLUSIONS: </B>The results indicated that GUSB levels could be used as a possible diagnosis biomarker in poisoning related to anticholinergic pesticide exposure. However, the use of GUSB to assess the chronic exposure to anticholinergic pesticides could be only performed in recent exposure (≈ 7 days after last exposure).