{Reference Type}: Journal Article
{Title}: Viral evolution of SIV chimpanzee toward HIV-1 using humanized mice.
{Author}: Curlin JZ;Schmitt K;Remling-Mulder L;Tibbitts CV;O'Connor S;Marx P;Akkina R;
{Journal}: J Med Primatol
{Volume}: 52
{Issue}: 5
{Year}: 2023 10 1
{Factor}: 0.821
{DOI}: 10.1111/jmp.12675
{Abstract}: HIV-1 emerged from SIVcpz evolving in humans. Humanized mice are an effective tool for assessing viral evolution via measuring viral loads, CD4+ T cell decline, and analyzing genetic changes. Four serial passages showed many non-synonymous mutations important for the adaptation and evolution of SIVcpz to human immune cells.