{Reference Type}: Journal Article
{Title}: A comprehensive review on Schisandrin and its pharmacological features.
{Author}: Wang X;Wang X;Yao H;Shen C;Geng K;Xie H;
{Journal}: Naunyn Schmiedebergs Arch Pharmacol
{Volume}: 397
{Issue}: 2
{Year}: 2024 02 1
{Factor}: 3.195
{DOI}: 10.1007/s00210-023-02687-z
{Abstract}: Schisandrin stands as one of the primary active compounds within the widely used traditional medicinal plant Schisandra chinensis (Turcz.) Baill. This compound exhibits sedative, hypnotic, anti-aging, antioxidant, and immunomodulatory properties, showcasing its effectiveness across various liver diseases while maintaining a favorable safety profile. However, the bioavailability of schisandrin is largely affected by hepatic and intestinal first-pass metabolism, which limits the clinical efficacy of schisandrin. In this paper, we review the various pharmacological effects and related mechanisms of schisandrin, in order to provide reference for subsequent drug research and promote its medicinal value.