{Reference Type}: Review
{Title}: COVID-19-related premature ovarian insufficiency: case report and literature review.
{Author}: Pankiewicz K;Chotkowska E;Nowakowska B;Gos M;Issat T;
{Journal}: Climacteric
{Volume}: 26
{Issue}: 6
{Year}: 2023 Dec 30
{Factor}: 3.024
{DOI}: 10.1080/13697137.2023.2246878
{Abstract}: <B>UNASSIGNED: </B>The aim of this study is to present the case report of a 36-year-old woman developing premature ovarian insufficiency (POI) after COVID-19 and review the literature referring to the possible impact of SARS-CoV-2 infection on female reproduction.<BR><B>UNASSIGNED: </B>A 36-year-old nulligravida with normal menstrual cycles, non-smoker, with a normal body mass index and no pelvic surgery or oncological treatment in her medical history presented to the Infertility Center of the Institute of Mother and Child in Warsaw after a year of unsuccessful attempts to get pregnant. During diagnostic process she was affected by COVID-19 with a mild manifestation and thereafter she presented amenorrhea with intense hot flushes. Further diagnostic confirmed the diagnosis of POI.<BR><B>UNASSIGNED: </B>There is a strong molecular basis for a possible effect of SARS-CoV-2 infection on the female reproductive system; however, the results of available research are conflicting. All of these aspects are discussed in detail.<BR><B>UNASSIGNED: </B>SARS-CoV-2 infection may cause serious complications that cast a long shadow on a patient's future life and health. Further research is needed to assess the real impact of SARS-CoV-2 infection on female reproductive health, as well as potential preventive and therapeutic strategies for women affected with COVID-19.