{Reference Type}: Journal Article
{Title}: Pyroglutamic Acidosis - An Underrecognised Entity Associated with Acetaminophen Use.
{Author}: Ng WW;Tong HF;Ng WY;Yeung JK;Young JK;Woo RK;Wong MM;
{Journal}: Rom J Anaesth Intensive Care
{Volume}: 30
{Issue}: 1
{Year}: 2023 Apr
暂无{DOI}: 10.2478/rjaic-2023-0004
{Abstract}: Pyroglutamic acidosis (PGA) is an underrecognized entity characterised by raised anion gap metabolic acidosis (RAGMA) and urinary hyper-excretion of pyroglutamic acid. It is frequently associated with chronic acetaminophen (APAP) ingestion. We report the case of a 73-year-old man with invasive pulmonary aspergillosis treated with voriconazole and APAP for analgesia with a cumulative dose of 160 g over 40 days. PGA was suspected as he developed severe RAGMA and common causes were excluded. Diagnosis was confirmed via urinary organic acid analysis which showed significant hyper-excretion of pyroglutamic acid. APAP was discontinued, and N-acetylcysteine (NAC) was administered. His RAGMA rapidly resolved following treatment.