{Reference Type}: Journal Article
{Title}: Photochemical Uncaging of Aldehydes and Ketones via Photocyclization/Fragmentation Cascades of Enyne Alcohols: An Unusual Application for a Cycloaromatization Process.
{Author}: Campbell A;Dos Santos NR;Alabugin I;
{Journal}: Molecules
{Volume}: 28
{Issue}: 15
{Year}: 2023 Jul 28
{Factor}: 4.927
{DOI}: 10.3390/molecules28155704
{Abstract}: We utilized a cycloaromatization reaction driven by relief of excited state antiaromaticity to photouncage aldehydes and ketones. We developed several synthetic routes towards the synthesis of photocaged carbonyls as allylically substituted 3-(2-(arylethynyl)phenyl)prop-2-en-1-ols. A library of photocaged aryl aldehydes and ketones containing donors and acceptors, as well as several photocaged fragrance aldehydes and the steroid 5α-cholestan- 3 -one, were synthesized and demonstrated photouncaging in good to excellent yields.