{Reference Type}: Multicenter Study
{Title}: Porto-sinusoidal vascular disorder (PSVD): Application of new diagnostic criteria in a multicenter cohort of patients.
{Author}: Gioia S;Baiocchini A;d'Amati G;Tavano D;Ridola L;Nardelli S;de Felice I;Lapenna L;Merli M;Pellicelli A;Giannelli V;Riggio O;
{Journal}: Dig Liver Dis
{Volume}: 56
{Issue}: 2
{Year}: 2024 Feb 5
{Factor}: 5.165
{DOI}: 10.1016/j.dld.2023.07.023
{Abstract}: <B>OBJECTIVE: </B>The term porto-sinusoidal vascular disorder (PSVD) was recently proposed to replace that of idiopathic non-cirrhotic portal hypertension (INCPH) to describe patients with typical histological lesions in absence of cirrhosis, irrespective of the presence/absence of portal hypertension (PH), and new diagnostic criteria were defined. The study aimed to compare the applicability between the diagnostic criteria of PSVD and those of INCPH.<BR><B>METHODS: </B>53 patients affected by PSVD were enrolled. Biochemical, clinical, ultrasound and histological data, the presence and type of associated diseases were recorded in a database. According to the new criteria, histological data and signs of PH were divided into specific and non-specific. Percutaneous and transjugular biopsies were compared to establish the usability of the two methods for diagnostic purposes.<BR><B>RESULTS: </B>In 85% of the patients the diagnosis of PSVD was obtained by applying the first criterion (25 had specific histological signs with specific signs of PH); one patient presented with specific histological signs but no PH. In 8 patients the diagnosis was obtained by applying the second criterion. 19% of patients had portal vein thrombosis. Finally, the prevalence of the various histological lesions was similar between the patients submitted to percutaneous and transjugular liver biopsy.<BR><B>CONCLUSIONS: </B>The study confirms that the diagnostic criteria of PSVD lead to the inclusion of a greater number of patients than INCPH.