{Reference Type}: Journal Article
{Title}: A Population-Based Study of Unfavorable Prognostic Factors Associated With Pyogenic Liver Abscess.
{Author}: Bläckberg A;Jönsson A;Svensson E;Sunnerhagen T;Kiasat A;Ljungquist O;
{Journal}: Open Forum Infect Dis
{Volume}: 10
{Issue}: 8
{Year}: 2023 Aug
{Factor}: 4.423
{DOI}: 10.1093/ofid/ofad352
{Abstract}: <B>UNASSIGNED: </B>Pyogenic liver abscess (PLA) is a rare entity that is associated with substantial mortality and morbidity. Our objective was to investigate variables associated with mortality and subsequent PLA in patients diagnosed with PLA in southern Sweden.<BR><B>UNASSIGNED: </B>We conducted a population-based observational study comprising all episodes of PLA that occurred between 2011 and 2020 in the county of Skåne, southern Sweden. The primary outcome was defined as all-cause 90-day mortality and the secondary outcome was defined as the occurrence of a subsequent PLA.<BR><B>UNASSIGNED: </B>A total of 452 episodes of PLA occurred in 360 patients during the study period. The 90-day mortality rate was 16% (n = 58) and the subsequent PLA rate was 20% (n = 92). In a multivariable logistic regression model, female sex (odds ratio [OR], 2.0 [95% confidence interval {CI}, 1.1-3.9]), malignancy (OR, 3.7 [95% CI, 1.9-7.1]), liver failure (OR, 6.3 [95% CI, 2.7-14.5]), and polymicrobial findings (OR, 3.8 [95% CI, 2.2-6.9]) were associated with death within 90 days (P < .05). Male sex (OR, 2.1 [95% CI, 1.2-3.6]), malignancy (OR, 2.1 [95% CI, 1.3-3.6]), age (64-74 years: OR, 2.5 [95% CI, 1.3-4.8]), and chronic liver disease (OR, 3.0 [95% CI, 1.4-6.5]) were associated with the risk of subsequent PLA (P ≤ .01).<BR><B>UNASSIGNED: </B>Identifying different clinical variables associated with an unfavorable outcome may improve the management and treatment of patients with PLA and thus prevent the risk of death and subsequent PLA.