{Reference Type}: Journal Article
{Title}: Unusual 5/5 fused bicyclosesquiterpenoids from Eupatorium adenophorum.
{Author}: Geng H;Luo JH;Gu WJ;Zhang JJ;Yang YX;Yu Y;
{Journal}: Fitoterapia
{Volume}: 170
{Issue}: 0
{Year}: 2023 Oct 5
{Factor}: 3.204
{DOI}: 10.1016/j.fitote.2023.105643
{Abstract}: The chemical analysis on the aerial sections of Eupatorium adenophorum Spreng. resulted in the identification of four unprecedented 5/5 fused bicyclosesquiterpenoids, eupatorid A (1), and its analogues named eupatorester A-C (2-4) using various chromatographic techniques. Their structures were unambiguously confirmed by detailed spectroscopic investigations (including 1D, 2D-NMR and HRMS), and single crystal X-ray diffraction. The anti-inflammatory activities, in vitro tumor growth inhibitory activities and antibacterial activities of these compounds were evaluated.