{Reference Type}: Systematic Review
{Title}: A Systematic Review of Adenoid Ameloblastoma: A Newly Recognized Entity.
{Author}: de Farias Morais HG;Gonçalo RIC;de Oliveira Costa CS;de Figueiredo Pires H;Mafra RP;de Morais EF;da Costa Miguel MC;de Almeida Freitas R;
{Journal}: Head Neck Pathol
{Volume}: 17
{Issue}: 3
{Year}: 2023 Sep 4
暂无{DOI}: 10.1007/s12105-023-01574-6
{Abstract}: <B>BACKGROUND: </B>Recently, a new odontogenic tumor has been described, the so-called adenoid ameloblastoma (AdAM). The aim of this review was to determine the clinical and imaging features of AdAM and to describe its main histopathological findings.<BR><B>METHODS: </B>The systematic review included published cases with a diagnosis of AdAM in the gnathic bones, which had sufficient clinical, imaging, and histopathological data to confirm its diagnosis. The following histopathological diagnostic criteria were adopted: presence of ameloblastoma-like components, duct-like structures, spiral cellular condensations, and a cribriform architecture.<BR><B>RESULTS: </B>Fifteen articles, corresponding to 30 cases of AdAM, were selected. Most cases affected men (63.3%), with a slight preference for the mandible (16:14) and the posterior region of gnathic bones was the most commonly affected site. The mean age at diagnosis was 40.8 years. Clinically, the lesions usually presented as a swelling (53.3%) and, radiographically, as a well-defined radiolucency (33.4%). Surgical resection (40%) was the most frequently adopted treatment and recurrence occurred in 30% of cases. Microscopic examination showed cribriform areas in most AdAM cases (93.3%); duct-like structures and spiral cellular condensations were seen in 100% of the cases.<BR><B>CONCLUSIONS: </B>The small number of reported cases, the existence of erroneous diagnoses, and the adoption of initial conservative management make it difficult to determine whether AdAM has a higher risk of recurrence or more aggressive biological behavior than conventional ameloblastomas.