{Reference Type}: Journal Article
{Title}: Antifungal activity of cisatracurium against fluconazole-resistant Candida isolates and its antibiofilm effects.
{Author}: do Nascimento FB;Valente Sá LG;de Andrade Neto JB;Cabral VP;Rodrigues DS;Barbosa AD;Moreira LE;Oliveira LC;Silva A;Lima IS;Silva J;Marinho ES;Santos HS;Cavalcanti BC;Morais MO;Júnior HV;Silva CR;
{Journal}: Future Microbiol
{Volume}: 18
{Issue}: 0
{Year}: 2023 07 31
{Factor}: 3.553
{DOI}: 10.2217/fmb-2022-0224
{Abstract}: Aim: To evaluate the antifungal activity of cisatracurium against Candida spp. resistant to fluconazole strains in planktonic and biofilm forms, in addition to determining its mechanism of action. Materials & methods: Antifungal activity and pharmacological interactions were determined using broth microdilution methods and the mechanism of action was evaluated by flow cytometry and molecular docking. Results: Cisatracurium presented antifungal activity against Candida spp. planktonic cells due to alterations of mitochondrial transmembrane potential leading to cellular apoptosis in addition to interacting with important targets related to cellular respiration, membrane and cell wall evidenced by molecular docking. Furthermore, the drug both prevented biofilm formation and impaired mature biofilms. Conclusion: Cisatracurium exhibits potential antifungal activity against Candida spp.