{Reference Type}: Journal Article
{Title}: Designing an effective malaria vaccine targeting Plasmodium vivax Duffy-binding protein.
{Author}: Dickey TH;Tolia NH;
{Journal}: Trends Parasitol
{Volume}: 39
{Issue}: 10
{Year}: 2023 10 21
{Factor}: 10.528
{DOI}: 10.1016/j.pt.2023.06.011
{Abstract}: Malaria caused by the Plasmodium vivax parasite is a major global health burden. Immunity against blood-stage infection reduces parasitemia and disease severity. Duffy-binding protein (DBP) is the primary parasite protein responsible for the invasion of red blood cells and it is a leading subunit vaccine candidate. An effective vaccine, however, is still lacking despite decades of interest in DBP as a vaccine candidate. This review discusses the reasons for targeting DBP, the challenges associated with developing a vaccine, and modern structural vaccinology methods that could be used to create an effective DBP vaccine. Next-generation DBP vaccines have the potential to elicit a broadly protective immune response and provide durable and potent protection from P. vivax malaria.